Insulin resistance

Insulin resistance is a metabolic condition characterized by the body's reduced ability to effectively use insulin, leading to elevated blood glucose levels and a range of associated health problems. 1

This condition is driven by excessive fat accumulation and oxidation, which can be exacerbated by a diet high in fat and low in sugar. 1 Additionally, certain substances such as aspirin and niacinamide have been shown to ameliorate insulin resistance. 1

Insulin resistance is also linked to various diseases, including breast cancer. The growth of breast cancer is favored by specific dietary fatty acids, visceral fat accumulation, and inadequate physical exercise, all of which are thought to interact in favoring the development of the insulin resistance syndrome. 2

Research has shown that blocking estrogen, either through the use of EM-652 or DHEA, can prevent obesity, diabetes, and other metabolic disorders associated with insulin resistance. 3 DHEA, in particular, has been found to be more potent than EM-652 in improving fasting insulinemia and insulin sensitivity.

Free fatty acids, particularly those that are polyunsaturated, have been shown to directly inhibit insulin signaling, leading to insulin resistance and potentially diabetes. 4 This inhibition is especially pronounced in individuals with chronic stress, which can lead to the overexpression of the enzyme aromatase, resulting in increased estrogen production.

Studies have also suggested that targeting serotonin, rather than gut bacteria, may be a more effective approach to curing metabolic diseases. 6 Additionally, fasting and exhaustive exercise can lead to insulin resistance and diabetes, as the body's fat stores are depleted and the liver begins to break down muscle tissue. 7

Finally, keto diets, which are often touted as a means of weight loss, may actually cause hyperlipidemia, liver and heart disease, and even diabetes type I due to the high levels of fat they induce. 8