Hyperammonemia

Hyperammonemia is the presence of too much ammonia in the blood 1. This condition can cause seizures, stupor, and is probably involved in mania and depression 5. Ammonia disturbs excitatory processes, and its elimination is mainly facilitated by carbon dioxide, which combines with it to form urea 5.

Estrogen's effects on cell water, causing it to become more like bulk (high dielectric) water, may contribute to its excitatory action and lower stimulation threshold in the gallbladder and brain 2. This is similar to the effects of fatigue or excessive oxygen, which also slow nerve conduction 2. The metabolism of fatigued muscle is similar to tumor metabolism, and hyperammonemia can be involved in these processes 5.

Hyperammonemia can be related to inefficient biological states, such as hypothyroidism, and its elimination is crucial for maintaining proper cellular function 5. The changes in cell water in the excited/fatigued state represent an increase in the water's structural temperature, which may imply that less carbon dioxide could remain dissolved during excitation 5.