Histamine

Histamine is a signal of danger or damage, activating many "immune" functions, including increasing the TLRs, and production of cytokines and antibodies. Energy deprivation activates the formation of histamine, which corresponds to the catabolic phase of an infection 1. Although inflammation can occur without infection, its presence is generally thought to indicate infection 1.

Histamine is an inflammation signal, and in insomnia, it is often elevated, contributing to an inflamed brain 2. Antihistamines can improve sleep by quieting the brain, and this effect can be achieved through good nutrition, such as consuming calcium, vitamin D, and thyroid 2. Cyproheptadine, an antihistamine, has been found to have a reparative effect, and its use can lead to a decrease in the need for it over time 5.

Histamine supports wakefulness, and too little can lower alertness 5. In the context of cancer, histamine is implicated in the growth and invasiveness of several types of cancer, and anticholinergic drugs can alleviate some of the symptoms of cancer by counteracting its effects 8. Progesterone has been found to affect all of the features of cancer metabolism in a positive way, and it can be used to restore normal metabolism 8.

The relationship between histamine and estrogen is complex, with histamine being one of the two legs on which estrogen stands, along with the cholinergic system 3. Blocking histamine or using anticholinergic drugs can effectively block the effects of estrogen, which is beneficial in the context of cancer 3.