GABA

GABA (gamma-aminobutyric acid) is an inhibitory neurotransmitter that plays a crucial role in regulating various physiological processes, including stress response, neural inhibition, and blood sugar regulation 1. It is closely related to other inhibitory neurotransmitters, such as glycine and succinic acid, and is involved in the regulation of insulin, progesterone formation, and tissue respiration 6.

GABA has a wide range of stress-blocking actions, including neural inhibition, progesterone promotion, and blood sugar regulation 7. It is also involved in the regulation of the GABA receptor system, which is affected by various substances, including Valium, progesterone, and pregnenolone 3. The GABA system is closely associated with the metabolism of succinic acid, which is an adaptogen that safely chelates toxic heavy metals out of mitochondria 7.

The GABA system is also affected by various polyunsaturated fatty acids, including arachidonic acid, which can inhibit glutamate uptake and have deleterious effects on GABA uptake in both astrocytes and neurons 8. However, the effects of arachidonic acid on GABA uptake are not as pronounced as its effects on glutamate uptake.

In contrast to the sedative and anti-convulsive effects of GABA, glutamic acid excites the brain, and its conversion to GABA is a key mechanism for turning off excitation and stress signals 3. The GABA system is also affected by various peptide signals that act parallel with glutamic acid to excite the brain and interfere with GABA.

Overall, the GABA system plays a crucial role in regulating various physiological processes, and its dysregulation can have significant consequences for health and well-being 1.